金沙集团1862cc(官方VIP认证)-ios/Android版

李帅帅教授

李帅帅,男,1986年11月生,博士,教授,研究生导师,金沙集团1862cc院长助理。

人才称号:

2018年,入选首批山东省青年科技托举人才工程(共20人)。

2019年,入选山东省高等学校优秀青年科技创新团队(2019KJM002),并担任天然产物及药物仿生合成与应用创新团队带头人。

社会兼职:

山东罗欣药业集团股份有限公司,特聘研究员

青岛瀚生生物科技股份有限公司,在职博士后

山东省科技特派员

研究方向:

基于过渡金属及有机小分子催化的串联去芳香化反应;研究绿色、温和条件下多步串联反应构建具有生物活性的有机分子,药物及其中间体。

教育经历:

2016.11-至今 青岛农业大学金沙集团1862cc, 教授

2011.9~2016.7 中科院成都有机所(硕博连读),博士,师从张晓梅研究员和董琳教授

2007.9~2011.7 临沂大学化学化工学院, 学士,师从彭安顺教授

近五年科研成果总结:

近五年,主持国家自然科学基金面上项目(21978144)和国家自然科学基金青年基金(21702117)、山东省重点研发计划(2019GSF108020, 2019RKB01027)等11项课题;在Acs Catalysis, Chemical Science, Green Chemistry, Organic Letters等国际著名SCI期刊发表论文50篇,其中,以第一或通讯作者发表SCI论文40篇,其中中科院Top一区论文22篇,ESI前1%高被引论文3篇;授权发明专利4件,其中技术转让1项;申请PCT国际专利1件;担任Chemical Communications, Advanced Synthesis & Catalysis, The Journal of Organic Chemistry, Organic Chemistry Frontiers等期刊的审稿人。

近五年主持代表性科研项目:

1. 融合sp3碳氢键官能化过程的去芳香化反应构建手性稠杂环化合物(21978144),国家自然科学基金面上项目, 主持,2020/01-2023/12,65 万元;

2. 神经类药物米安色林及其类似物的高效合成新方法(2019GSF108020),山东省重点研发计划,主持,2019/01-2020/12,15 万元;

3. “经略海洋”战略背景下的药物创制研究(2019RKB01027),山东省重点研发计划,主持,2019/12-2021/10,10 万元;

4. 海洋天然产物及药物仿生合成与应用(2019KJM002),山东省高等学校优秀青年科技创新团队,带头人,2019/03-2022/03,20 万元;

5. 基于氢迁移策略的七元环构建新方法(21702117),国家自然科学基金青年基金, 主持,2018/01-2020/12,27.6 万元;

6. 新型氢迁移/环化串联反应构建中环化合物研究(ZR2017BB005),山东省自然科学基金博士基金,主持,2017/8-2019/12,8 万元;

7. 山东省青年科技托举人才工程,2018/10-2021/10,15 万元;

8. 山东省博士后创新资助项目,2021/10-2022/10,3 万元;

9. 青岛农业大学高层次人才启动基金(6651118009),2018/12-2023/12,主持,100 万元;

10. 青岛科技大学化学学部开放基金(QUSTHX202004),2019/11-2020/11,主持,3万元;

11. 3,4-二氢-3-(2-羟基苯甲酰)-2(1H)-喹啉酮类生物活性分子的开发与利用(6602421167),主持,技术转化,2021/10-2024/10,5万元。

获奖情况:

国家级大学生创新训练指导教师,2020年,2021年

青岛农业大学优秀学士论文指导教师,2019年,2020年

长和国际奖教金,2020年

青岛农业大学优秀班主任,2019年

青岛农业大学先进个人,2018年,2019年,2021年

优秀党员,2021年

山东化学化工学会科学技术奖,2022年

最美教师,2022年

中国博士后创新创业大赛优胜奖,2022年

教学情况:

主讲《高等有机化学》、《有机化学B》、《有机化学C》、《应用化学前沿》、《基础化学实验》等课程。

代表性成果列表(第一或通讯作者):

40. Fangzhi Hu, Liang Wang, Peng Wang, Zhanshuai Ding, Yuzhuo Chen, LubinXu, Xiong-Li Liu, Shuai-Shuai Li, Switchable construction of oxa-heterocycles with diverse ring sizes via chemoselective cyclization controlled by dibrominated compounds, Org. Chem. Front. 2022, DOI 10.1039/d2qo01273a. Invited Review (IF = 5.456, 中科院top一区)

39. Fangzhi Hu,† Yao-Bin Shen,† Liang Wang, Shuai-Shuai Li*, Merging dearomatization with redox-neutral C(sp3)–H functionalization via hydride transfer/cyclization: recent advances and perspectives, Org. Chem. Front. 2022, 9, 5041-5052. Invited Review (IF = 5.456, 中科院top一区)

38. Ronghao Xie,‡ Shixiao Chen,‡ Yufeng Wang, Xiangcong Yin, Shuai-Shuai Li*, Lubin Xu and Liang Wang*, Controllable construction of pharmaceutically significant scaffolds of 2,3-dihydroquinolin-4-one and benzoazepine-5-one via redox-neutral cascade hydride transfer/cyclization, Org. Chem. Front. 2022, DOI 10.1039/d2qo01103d. (IF = 5.456, 中科院top一区)

37. Chunyan Ge, Liang Wang, Fangzhi Hu, Zhanshuai Ding, Xinyao Li, Deshuai Xiao, Jiayi Wang, Shuai-Shuai Li*, HFIP-mediated imidization of electron-rich arenes with in situ formed spiroindolenines as new imidization reagents for facile construction of 2-arylspiroindolenines, Org. Chem. Front. 2022, 9, 1696-1702. (IF = 5.456, 中科院top一区)

36. Lianyi Cao, Fangzhi Hu, Hongmei Sun, Xiaomei Zhang,* Shuai-Shuai Li*, Redox-triggered dearomative [5+1] annulation of indoles with O-alkyl ortho-oxybenzaldehydes for synthesis of spirochromanes, Org. Chem. Front. 2022, 9, 1668-1674. (IF = 5.456, 中科院top一区)

35. Fangzhi Hu, Xinyao Li, Zhanshuai Ding, Liang Wang, Chunyan Ge, Lubin Xu, and Shuai-Shuai Li*, Divergent Synthesis of [3,4]-Fused 3‑Alkenyl-Oxindoles via Propargyl Alcohol-Triggered C(sp3)−H Functionalization, ACS Catal. 2022, 12, 943-952. (IF = 13.70, 中科院top一区)

34. Ronghao Xie, Shixiao Chen, Xianping Xiang, Xiangcong Yin, Lubin Xu, Shuai-Shuai Li,* Liang Wang* and Fengying Dong*, Diastereoselective construction of structurally diverse 2,3-dihydroquinolin-4-one scaffolds via redox neutral cascade [1,7]-hydride transfer/cyclization, Org. Chem. Front. 2022, 9, 660–666. (IF = 5.456, 中科院top一区)

33. Fangzhi Hu, Liang Wang, Chunyan Ge, Xinyao Li, Zhanshuai Ding, Lubin Xu, Shuai-Shuai Li*,Divergent α-Functionalization of Cyclic Amines via Ring Construction by Molecular O2 Oxidized Dearomatization and Ring Deconstruction by Aromatization Driven C-C σ-Bond Cleavage, Green Chem. 2021, 23, 5535–5541 (IF = 11.034, 中科院top一区)

32. Mengzhu Guo, Fengying Dong, Xiangcong Yin, Lubin Xu, Liang Wang*, and Shuai-Shuai Li*, Facile Syntheses of Tetrahydroquinolines and 1,2-Dihydroquinolines via Vinylogous Cascade Hydride Transfer/Cyclization, Org. Chem. Front. 2021, 8, 2224–2231. (IF = 5.456, 中科院top一区)

31. Xiaoyu Yang, Jianlin Liu, Fangzhi Hu, Hongmei Sun, Liang Wang*, and Shuai-Shuai Li*, Diverse Application of 4-Hydroxycoumarin in Syntheses of Tetrahydroquinoline and Zwitterionic Biscoumarin Derivatives, Chin. J. Org. Chem., 2021, 41, 2788-2799. (中国期刊 《有机化学》,中科院三区)

30. Xiaoyu Yang, Liang Wang, Fangzhi Hu, Lubin Xu, Sanming Li, and Shuai-Shuai Li*, Redox-Triggered Switchable Synthesis of 3,4-Dihydroquinolin-2(1H)-one Derivatives via Hydride Transfer/N-Dealkylation/N-Acylation, Org. Lett. 2021, 23, 358–364. (IF = 6.005, 中科院top一区)

29. Kejin Yuan, Fengying Dong, Xiangcong Yin, Shuai-Shuai Li*, Liang Wang,* Lubin Xu*, The dual alkylation of the C(sp3)-H bond of the cyclic α-methyl-N-sulfonyl imines via sequential condensation/hydride transfer/cyclization process, Org. Chem. Front. 2020, 7, 3868–3873. (IF = 5.456, 中科院top一区)

28. Yingying Xing, Fengying Dong, Xiangcong Yin, Liang Wang* and Shuai-Shuai Li*, Facile Construction of 3,4-dihydro-2H-1,2,4-Benzothiadiazine 1,1-Dioxides via Redox-Neutral Cascade Condensation/[1,7]-Hydride Transfer/Cyclization, Asian J. Org. Chem. 2020, 9, 1787-1792. (IF = 3.319, 中科院三区)

27. Kang Duan, Hongjin Shi, Lin-Xuan Wang, Shuai-Shuai Li*, Lubin Xu, Jian Xiao*, Hydride Transfer Enabled Switchable Dearomatization of Indoles in the Carbocyclic Ring and the Pyrrole Ring, Org. Chem. Front. 2020, 7, 2511–2517. (IF = 5.456, 中科院top一区)

26. Fangzhi Hu, Liang Wang, Lubin Xu and Shuai-Shuai Li*, Aromatization-driven Deconstruction/refunctionalization of Unstrained Rings, Org. Chem. Front. 2020, 7, 1570–1575. (IF = 5.456, 中科院top一区)

25. Xiaoyu Yang, Fangzhi Hu, Liang Wang, Lubin Xu and Shuai-Shuai Li*, Hydrogen-bonding-assisted redox-neutral construction of tetrahydroquinolines via hydride transfer, Org. Biomol. Chem. 2020, 18, 4267–4271. (IF = 3.876, 中科院三区)

24. Hongjin Shi, Liang Wang, Shuai-Shuai Li*, Yongjun Liu, and Lubin Xu*, Divergent syntheses of spirooxindoles from oxindole-embedded four-membered synthon via cycloaddition reactions, Org. Chem. Front. 2020, 7, 747–755. (IF = 5.456, 中科院top一区)

23. Hongjin Shi, Lubin Xu, Didi Ren, Liang Wang,* Weisi Guo and Shuai-Shuai Li*, Fluorinated alcohol mediated N,N’-dialkylation of amino acid derivatives via cascade [1,5]-hydride transfer/cyclization for concise synthesis of tetrahydroquinazoline, Org. Biomol. Chem. 2020, 18, 895-904. (IF = 3.876, 中科院三区)

22. Lan Zhou, Yao-Bin Shen, Xiao-De An, Xian-Jiang Li, Shuai-Shuai Li*, Qing Liu, and Jian Xiao*, Redox-Neutral β‑C(sp3)−H Functionalization of Cyclic Amines via Intermolecular Hydride Transfer, Org. Lett. 2019, 21, 8543−8547. (IF = 6.005, 中科院top一区)

21. Guangxian Bai, Fengying Dong, Lubin Xu, Yongjun Liu, Liang Wang,* and Shuai-Shuai Li*, Controllable Syntheses of Spiroindolenines and Benzazepinoindoles via Hexafluoroisopropanol-Mediated Redox-Neutral Cascade Process, Org. Lett. 2019, 21, 6225-6230. (IF = 6.005, 中科院top一区)

20. Shuai-Shuai Li, Shuai Zhu, Chunqi Chen, Kang Duan, Qing Liu, and Jian Xiao*, Redox-Neutral Cascade Cyclizations for Construction of Spirocyclic Bisoxindoles Featuring a [3,4]-Fused Oxindole Moiety, Org. Lett. 2019, 21, 1058-1062. (IF = 6.005, 中科院top一区)

19. Didi Ren, Lubin Xu, Liang Wang*, Shuai-Shuai Li*, Catalytic Formal Benzylic C−H Bond Functionalization of 2,5-Dialkylfuran Derivatives with Ferrocenyl Alcohols as Alkylation Reagents, Org. Lett. 2019, 21, 627–631. (IF = 6.005, 中科院top一区)

18. Shuai Zhu, Chunqi Chen, Kang Duan, Yun-Ming Sun, Shuai-Shuai Li*, Qing Liu, and Jian Xiao*, Cascade [1,5]-Hydride Transfer/Cyclization for Synthesis of [3,4]-Fused Oxindoles, J. Org. Chem. 2019, 84, 8440−8448. (IF = 4.354, 中科院二区)

17. Xintong Lv,# Fangzhi Hu,# Kang Duan, Shuai-Shuai Li*, Qing Liu, and Jian Xiao*, Aromatization-Driven Cascade [1,5]-Hydride Transfer/Spirocyclization Promoted by Fluorinated Alcohols, J. Org. Chem. 2019, 84, 1833-1844. (IF = 4.354, 中科院二区, 高被引论文)

16. Shuai-Shuai Li, Xintong Lv, Didi Ren, Chang-Lun Shao, Qing Liu and Jian Xiao*, Redox-Triggered Cascade Dearomative Cyclizations Enabled by Hexafluoroisopropanol, Chem. Sci. 2018, 9, 8253–8259. (IF = 9.825, 中科院top一区)

15. Shuai-Shuai Li,# Lan Zhou,# Liang Wang, Huaili Zhao, Liping Yu, and Jian Xiao*, Organocatalytic C(sp3)-H Functionalization via Carbocation-Initiated Cascade [1,5]-Hydride Transfer/Cyclization: Synthesis of Dihydrodibenzo[b,e]azepines, Org. Lett. 2018, 20, 138-141. (IF = 6.005, 中科院top一区)

14. Chunqi Chen, Lubin Xu, Liang Wang* and Shuai-Shuai Li*, Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization, Org. Biomol. Chem. 2018, 16, 7109–7114. (IF = 3.876, 中科院三区)

13. Shuai-Shuai Li, Shiheng Fu, Liang Wang, Lubin Xu, and Jian Xiao, t-BuOK-Mediated Oxidative Dehydrogenative C(sp3)-H Arylation of 2-Alkylazaarenes with Nitroarenes, J. Org. Chem. 2017, 82, 8703. (IF = 4.354, 中科院二区)

12. Shuai-Shuai Li, Lin Wu, Liu Qin, Yu-Qin Zhu, Fu Su, Yan-Jun Xu*, Lin Dong*, Iridium(III)-catalyzed Tandem [3 + 2] Annulation: Synthesis of Spirocyclic Phosphoramide Derivatives, Org. Lett. 2016, 18, 4214-4217. (IF = 6.555, 中科院top一区)

11. Shuai-Shuai Li, Cheng-Qi Wang, Hui Lin, Xiao-Mei Zhang, Lin Dong*, Rhodium(III)-Catalyzed Oxidative Annulation of 7Azaindoles and Alkynes via Double C-H Activation, Org. Lett. 2015, 17, 3018-3021. (IF = 6.555, 中科院top一区)

10. Shuai-Shuai Li, Hui Lin, Chen-Fei Liu, Ying-Qi Xia, Xiao-Mei Zhang, Lin Dong*, Rhodium-Catalyzed Tandem Annulation Reactions of 7-Azaindoles with Electron-Deficient Olefins via Double C-H Activation, Adv. Synth. Catal. 2016, 358, 1595-1601.

9. Shuai-Shuai Li#, Ying-Qi Xia#, Chen-Fei Liu, Guo-Tai Zhang, Xiao-Mei Zhang, Lin Dong*, Diverse Reactivity in a Rhodium(III)-Catalyzed Vinylic sp2 C–H Bond Functionalization: Synthesis of Fused Polycyclic Heteroarenes or Conjugated Dienes, Adv. Synth. Catal. 2016, 358, 3724-3729.

8. Shuai-Shuai Li#, Chen-Fei Liu#, Guo-Tai Zhang, Ying-Qi Xia, Wei-Huan Li, Lin Dong*, A Convenient One-Pot Route to Screw-Shaped [5]Azahelicenes via Rhodium(III)-Catalyzed Multiple C−H Bond Activation, Chemistry – An Asian Journal 2017, 12, 415-418.

7. Shuai-Shuai Li, Ying-Qi Xia, Fang-Zhi Hu, Chen-Fei Liu, Xiao-Mei Zhang, Lin Dong*, IrIII-Catalyzed One-Pot Cascade Synthesis of Pentacyclic-Fused Carbazoles from Indoles and Diazoes, Chemistry – An Asian Journal 2016, 11, 3165-3168.

6. Shuai-Shuai Li, Cheng-Qi Wang, Hui Lin, Xiao-Mei Zhang, Lin Dong*, Rhodium(III)-catalyzed C–C coupling of 7-azaindoles with vinyl acetates and allyl acetates, Org. Biomol. Chem. 2016, 14, 229-237.

5. Shuai-Shuai Li#, Liu Qin#, Lin Dong*, Rhodium-catalyzed C–C Coupling Reactions via Double C–H Activation, Org. Biomol. Chem. 2016, 14, 4554-4570. (过渡金属铑催化双C-H活化综述,高被引论文)

4. Shuai-Shuai Li, Chen-Fei Liu, Ying-Qi Xia, Xiao-Mei Zhang, Lin Dong*, A Unique Annulation of 7-Azaindoles with Alkenyl Esters to Produce π-Conjugated 7-Azaindole Derivatives, Org. Biomol. Chem. 2016, 14, 5214-5218.

3. Shuai-Shuai Li#, Wei-Huan Li#, Guo-Tai Zhang, Ying-Qi Xia, Xiao-Mei Zhang, Lin Dong*, One-pot Construction of Fused Polycyclic Heteroarenes Involving 7-Azaindoles and α,β-Unsaturated Ketones, Org. Biomol. Chem. 2016, 14, 7859-7863.

2. Shuai-Shuai Li, Hui Lin, Xiao-Mei Zhang, Lin Dong*, Ruthenium-catalyzed direct C3 alkylation of indoles with α,β-unsaturated ketones, Org. Biomol. Chem. 2015, 13, 1254-1263.

1. Shuai-Shuai Li, Cheng-Qi Wang, Wei-Huan Li, Xiao-Mei Zhang, Lin Dong*, Rhodium-catalyzed Selective Oxidative Coupling of 7-Azaindoles, Tetrahedron 2016, 72, 2581-2586.

授权专利:

1. 3,4-二氢-3-(2-羟基苯甲酰)-2(1H)-喹啉酮活性骨架及合成方法和应用

(专利号:ZL 201910530179.4)

发明人:李帅帅、胡方芝、王亮、徐鲁斌、杨晓宇

2. 一种氧气促进的去芳香化反应在构建螺环二烯酮骨架中的应用

  • 专利号:ZL 202110792351.0)

发明人:李帅帅、胡方芝、李鑫瑶

3. 一种双香豆素内盐生物活性骨架的绿色合成方法及应用

  • 专利号:ZL 202110224263.0)

发明人:李帅帅、胡方芝、王亮、徐鲁斌、杨晓宇

联系方式:18661797516;邮箱:flyshuaishuai@126.com

1、3,4-二氢-3-(2-羟基苯甲酰)-2(1H)-喹啉酮活性骨架及合成方法和应用,201910530179.4,2020.08.04,1/5;

2、一种苯酚类化合物的苄基化合成方法,201810725188.4,2020.07.21,2/3; 3、一种基于靛红骨架的苯并[b,e]氮杂卓化合物及其制备方法,201810979889.0,2019.12.10,3/4;

4、一种氮杂环取代对醌骨架螺环化合物的合成方法,201810733970.0,2020.05.19,3/3

联系方式:18661797516;邮箱:flyshuaishuai@126.com

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